Tc99mMDPBoneScanQualityChecker

Tc-99m MDP Bone Scan Quality Checker — Quality control of Tc-99m MDP for bone scintigraphy

ℹ️ Utility checks critical parameters of Tc-99m MDP:

• Radiochemical purity (≥90%)
• Free technetium (<5%)
• Colloidal technetium (<5%)
• pH, shelf-life, endotoxins, sterility

⚠️ CRITICAL: Colloidal technetium accumulates in liver, masking metastases!

Tc-99m MDP is most common drug for skeletal scintigraphy.

Complex stability is limited to 6 hours.

Usage

Tc99mMDPBoneScanQualityChecker.exe → demo mode (console output)

Tc99mMDPBoneScanQualityChecker.exe input.csv output.json → evaluate your data

Input format

BatchNumber,RadiochemicalPurityPercent,FreeTechnetiumPercent,HydrolyzedReducedTcPercent,pH,TimeSincePreparationMin,ActivityMBq,SterilityTest,EndotoxinsEU_per_mL

Example

MDP-2026-001,96.0,2.0,2.0,7.0,30.0,1000.0,0,10.0

— WHY IS THIS NEEDED?

Tc-99m MDP (Methylenediphosphonate) is gold standard for skeleton imaging.

• Mechanism: chemosorption on bone hydroxyapatite surface.
• Requires high radiochemical purity to avoid accumulation in soft tissues.
• Free technetium gives background in thyroid and stomach.
• Colloidal technetium (hydrolyzed) gives background in liver and spleen.

⚠️ CRITICAL:

• Radiochemical purity ≥90% (recommended >95%) — guarantee of high bone/soft tissue contrast.
• Free technetium <5% — minimization of artifacts.
• Colloidal technetium <5% — critical for excluding false positives in abdominal cavity.
• pH 6.0-8.0 — complex stability.
• Time since preparation ≤6 hours — in vitro stability limit.
• Endotoxins <175 EU/mL — standard for parenteral drugs.
• Sterility — MANDATORY.

Key features

• Separate control of free and colloidal technetium.
• Drug shelf-life monitoring.
• Suitability assessment for mass diagnostics.
• Compliance with Pharmacopoeia requirements for Tc-99m radiopharmaceuticals.

Critical parameters

• Radiochemical purity: ≥90.0%
• Free technetium: <5.0%
• Colloidal technetium: <5.0%
• pH: 6.0–8.0
• Time since preparation: ≤360 min (6 h)
• Endotoxins: <175 EU/mL
• Sterility: no growth

💡 Usage tips:

1. Radiochemical purity determined by TLC (two solvents: acetone and saline).

2. Protect drug from light.

3. Use drug within 4-6 hours after preparation for maximum efficacy.

4. If high colloid levels, check generator eluate quality (aluminum presence).

5. MDP is stable at room temperature.

⚠️ Note: Tc-99m MDP is most frequently used radiopharmaceutical in world. Quality of this drug directly affects diagnostic ability to detect small metastases and stress fractures. Even small amount of colloids can create serious diagnostic confusion.