Y90MicrosphereRadioembolizationChecker

Y-90 Microsphere Radioembolization Checker — Quality control of Y-90 microspheres for SIRT

ℹ️ Utility checks critical parameters of Y-90 microspheres:

• Particle size (10-60 μm) and D90 (<70 μm)
• Radiochemical purity (≥99%)
• Free yttrium (<0.1%)
• Lung shunt fraction (<15%) — CRITICAL!

⚠️ CRITICAL: Lung shunting >15% is contraindication for procedure!

Y-90 microspheres are used for selective internal radiation therapy (SIRT) of liver.

Free Y-90 accumulates in bones, causing severe myelosuppression.

Usage

Y90MicrosphereRadioembolizationChecker.exe → demo mode (console output)

Y90MicrosphereRadioembolizationChecker.exe input.csv output.json → evaluate your data

Input format

BatchNumber,MicrosphereType,MeanParticleSizeUm,ParticleSizeD90Um,PolydispersityIndex,RadiochemicalPurityPercent,FreeYttriumPercent,ActivityGBq,SpecificActivityGBq_per_g,pH,SterilityTest,EndotoxinsEU_per_mL,LungShuntFraction

Example

Y90-GLASS-2026-001,Glass,30.0,40.0,0.1,99.9,0.01,5.0,2500.0,7.0,0,5.0,3.0

— WHY IS THIS NEEDED?

Y-90 microspheres (glass or resin) are drug for treating inoperable liver tumors.

• Mechanism: embolization of tumor capillaries + local beta irradiation.
• Particle size is critical: they must lodge in precapillaries but not in major vessels.
• Free Y-90 is toxic to bone marrow.
• Lung shunting (LSF) determines procedure eligibility.

⚠️ CRITICAL:

• Particle size 10-60 μm — optimal range for capillary embolization.
• D90 <70 μm — guarantee of absence of large aggregates.
• Radiochemical purity ≥99% — minimization of free yttrium.
• Free yttrium <0.1% — prevention of myelosuppression.
• Lung shunt fraction (LSF) <15% — safety limit for lungs.
• pH 6.0-8.0 — physiological range.
• Endotoxins <175 EU/mL — standard for intravascular drugs.
• Sterility — MANDATORY.

Key features

• Strict control of lung shunt fraction (LSF).
• Assessment of particle size and polydispersity.
• Radiochemical purity and free yttrium check.
• Support for both microsphere types (Glass/Resin).
• Compliance with GMP requirements for radioembolization.

Critical parameters

• Particle size: 10–60 μm
• D90: <70 μm
• PDI: <0.2
• Radiochemical purity: ≥99.0%
• Free yttrium: <0.1%
• Lung shunt fraction (LSF): <15.0%
• pH: 6.0–8.0
• Endotoxins: <175 EU/mL
• Sterility: no growth

💡 Usage tips:

1. Particle size determined by laser diffraction or microscopy.

2. LSF measured before procedure using Tc-99m MAA (macroaggregated albumin).

3. Drug requires special beta radiation protection measures during handling.

4. Glass microspheres have higher specific activity than resin ones.

5. Procedure performed by interventional radiologist under angiography control.

⚠️ Note: Y-90 radioembolization is complex hybrid procedure combining surgery and radiotherapy. Microsphere quality directly affects patient survival. This utility serves as final safety barrier before drug administration into hepatic artery.