Tc99mHMPAOBrainPerfusionStabilityChecker

Tc-99m HMPAO Brain Perfusion Stability Checker — Quality control of Tc-99m HMPAO stability

ℹ️ Utility checks critical stability parameters of Tc-99m HMPAO:

• Lipophilic complex fraction (≥80%)
• Time since preparation (<30 min)
• Secondary hydrophilic complex (<20%)
• Free technetium (<5%)

⚠️ CRITICAL: HMPAO rapidly converts to hydrophilic form!

Only lipophilic form crosses blood-brain barrier.

Drug must be administered within 30 minutes after preparation.

Usage

Tc99mHMPAOBrainPerfusionStabilityChecker.exe → demo mode (console output)

Tc99mHMPAOBrainPerfusionStabilityChecker.exe input.csv output.json → evaluate your data

Input format

BatchNumber,RadiochemicalPurityPercent,SecondaryComplexPercent,FreeTechnetiumPercent,TimeSincePreparationMin,MaxAllowedTimeMin,pH,ActivityMBq,StorageCondition

Example

HMPAO-2026-001,82.0,10.0,5.0,15.0,30.0,7.4,700.0,RoomTemp

— WHY IS THIS NEEDED?

Tc-99m HMPAO (Ceretec) is drug for brain perfusion imaging.

• Mechanism based on passive diffusion of lipophilic complex through BBB.
• Inside brain cell, complex converts to hydrophilic form and gets "trapped".
• However, outside cell, drug also rapidly converts to secondary hydrophilic complex that cannot enter brain.
• This conversion occurs within 15-30 minutes after preparation.

⚠️ CRITICAL:

• Radiochemical purity (lipophilic form) ≥80% — guarantee of brain penetration.
• Time since preparation ≤30 minutes — critical stability factor.
• Secondary complex <20% — indicator of drug degradation.
• Free technetium <5% — minimization of background in thyroid and stomach.
• pH 7.0-8.0 — solution stabilization.
• Store at room temperature (do not refrigerate!).

Key features

• Monitoring of drug "shelf-life after preparation".
• Assessment of lipophilic form fraction, critical for diagnostics.
• Warning about need for immediate administration.
• Compliance with manufacturer and Pharmacopoeia requirements.

Critical parameters

• Lipophilic form (RCP): ≥80.0%
• Secondary complex: <20.0%
• Free technetium: <5.0%
• Time since preparation: ≤30 min
• pH: 7.0–8.0

💡 Usage tips:

1. Prepare drug immediately before study.

2. Use TLC (acetone) for rapid RCP check before administration.

3. If more than 30 minutes have passed, drug is considered unsuitable for brain imaging.

4. Do not use drug if it has been refrigerated.

5. Administer drug as bolus to ensure clear first-pass circulation picture.

⚠️ Note: Unlike most radiopharmaceuticals, HMPAO stability is measured not in days but in minutes. This utility serves as strict timer and quality controller, preventing administration of degraded drug to patient, which would show only background in soft tissues but not in brain.