ExhaledGasScavengingAndRecoveryQC
Exhaled Gas Scavenging & Recovery QC
medical_devices Hyperpolarized Xenon RPH Xe-129 medical gases CSV→JSON URS & FS rule-based
Open selectionUtility description: Exhaled Gas Scavenging & Recovery QC
Exhaled Gas Scavenging & Recovery QC — Exhaled Gas Scavenging and Recovery Analyzer
ℹ️ Utility controls economics and safety of gas return process:
• Collection efficiency (>85%)
• CO2 and moisture removal
• Isotopic purity preservation
⚠️ CRITICAL: Loss of enriched Xe-129 is economically unviable!
Trap contamination with water can disable the system.
Usage:
ExhaledGasScavengingAndRecoveryQC.exe → demo mode (console output)
ExhaledGasScavengingAndRecoveryQC.exe input.csv output.json → evaluate your data
Input format:
BatchNumber,ProductName,Administered_Volume_L,Exhaled_Captured_Volume_L,Initial_Xe_Purity_Percent,Recovered_Xe_Purity_Percent,Recovered_CO2_ppm,Recovered_H2O_ppm,Recovered_O2_ppm,Min_Recovery_Eff,Max_CO2
Example:
XE-REC-2026-001,HP-Xe-129 (90% enriched),1.0,0.92,90.0,89.5,50.0,2.0,21.0,85.0,100.0
— WHY IS THIS NEEDED?
Xenon recovery is critical for sustainability of HP-MRI programs:
• Enriched Xe-129 costs thousands of dollars per liter
• Patient exhales most of the administered gas
• Scavenging systems collect gas, clean it from CO2 and moisture
• Cleaned gas can be reused after re-polarization
• Inefficient cleaning leads to cryogenic trap failure (water freezing)
⚠️ CRITICAL:
• Collection efficiency ≥85% — economic standard
• CO2 level ≤100 ppm — requirement for adsorbent protection
• Moisture ≤5 ppm — critical for cryogenic systems
• Isotopic purity must remain at ≥90% level
Key features:
• Mass balance calculation of administered vs collected gas
• Scrubber (CO2/H2O) efficiency control
• Assessment of recovered gas suitability for re-polarization
• Session economic efficiency monitoring
Critical parameters:
• Recovery Efficiency: ≥85%
• CO2: ≤100 ppm
• H2O: ≤5 ppm
• Purity: ≥90%
💡 Usage tips:
1. Regularly check patient breathing circuit for leaks
2. Monitor chemical filter (soda lime) lifespan
3. Use humidity sensors at trap outlet
4. Perform periodic mass-spectrometric analysis of recovered mixture
5. Maintain log of recovered gas volume for equipment ROI calculation
⚠️ Note: Unlike standard medical gases, xenon is not chemically consumed, it is only "lost" physically. The utility helps turn this expense item into a savings item through closed-loop usage.input.csv
BatchNumber,ProductName,Administered_Volume_L,Exhaled_Captured_Volume_L,Initial_Xe_Purity_Percent,Recovered_Xe_Purity_Percent,Recovered_CO2_ppm,Recovered_H2O_ppm,Recovered_O2_ppm,Min_Recovery_Eff,Max_CO2 XE-REC-2026-001,HP-Xe-129 (90% enriched),1.0,0.92,90.0,89.5,50.0,2.0,21.0,85.0,100.0 XE-REC-2026-002,HP-Xe-129 (85% enriched),0.8,0.60,85.0,84.0,150.0,8.0,21.0,85.0,100.0 XE-REC-2026-003,HP-Xe-129 (Recycled),1.0,0.95,92.0,91.8,20.0,1.0,21.0,85.0,100.0
URS & FS — user requirements and functional specification
URS & FS — User Requirements and Functional Specification
This document defines the controlled interface and behaviour of ExhaledGasScavengingAndRecoveryQC for “Exhaled Gas Scavenging & Recovery QC”. Limits from the source description are an initial configuration and shall be reconciled with the approved specification, study protocol, equipment instructions and local SOPs before production use.
Domain constraints and critical parameters
- Recovery Efficiency: ≥85%
- CO2: ≤100 ppm
- H2O: ≤5 ppm
- Purity: ≥90%
URS — User Requirements Specification
| ID | Requirement | Criticality | Acceptance criterion |
|---|---|---|---|
| URS-001 | The utility shall accept input.csv with the exact headers defined by the data contract. | High | The file is processed without manual header renaming. |
| URS-002 | The utility shall perform a deterministic assessment for “Exhaled Gas Scavenging & Recovery QC”. | High | PASS / WARNING / FAIL is produced for each row. |
| URS-003 | Required fields, types, ranges, units and data consistency shall be validated before domain rules. | High | Schema errors are separated from nonconformities. |
| URS-004 | Critical limits from the description and approved local configuration shall create a critical finding. | High | A critical rule violation results in FAIL. |
| URS-005 | The result shall be written to machine-readable output.json. | High | JSON contains source values, checks, warnings and failures. |
| URS-006 | The conformity decision shall not use machine learning. | Medium | The result is reproducible from explicit rules and inputs. |
| URS-007 | Traceability of batch, source file, rule version and final status shall be retained. | High | QA/QC can reproduce the decision. |
| URS-008 | The utility shall have exactly one primary portal tag: medical_devices. | Medium | The other api / instrumental / medical_devices tags are absent. |
| URS-009 | Documentation shall support IQ/OQ/PQ or equivalent CSA/CSV verification. | Medium | The contract, test scenarios and change-control rules are supplied with the utility. |
input.csv data contract
| # | Field | Type | Unit | Sample | Purpose |
|---|---|---|---|---|---|
| 1 | BatchNumber | string | as specified | XE-REC-2026-001 | Batch/lot identifier for traceability. |
| 2 | ProductName | string | as specified | HP-Xe-129 (90% enriched) | Name of the controlled product, gas, procedure or equipment. |
| 3 | Administered_Volume_L | decimal | L | 1.0 | Controlled input.csv field: Administered Volume L. |
| 4 | Exhaled_Captured_Volume_L | decimal | L | 0.92 | Controlled input.csv field: Exhaled Captured Volume L. |
| 5 | Initial_Xe_Purity_Percent | decimal | % | 90.0 | Xenon parameter: concentration, isotope fraction, activity, volume or purity depending on the field. |
| 6 | Recovered_Xe_Purity_Percent | decimal | % | 89.5 | Xenon parameter: concentration, isotope fraction, activity, volume or purity depending on the field. |
| 7 | Recovered_CO2_ppm | decimal | ppm | 50.0 | Oxygen concentration or flow; a breathing-mixture safety and/or polarization-retention parameter. |
| 8 | Recovered_H2O_ppm | decimal | ppm | 2.0 | Moisture content affecting gas purity, T1 and equipment condition. |
| 9 | Recovered_O2_ppm | decimal | ppm | 21.0 | Oxygen concentration or flow; a breathing-mixture safety and/or polarization-retention parameter. |
| 10 | Min_Recovery_Eff | decimal | as specified | 85.0 | Xenon capture, recovery or recycling metric. |
| 11 | Max_CO2 | decimal | °C | 100.0 | Oxygen concentration or flow; a breathing-mixture safety and/or polarization-retention parameter. |
BatchNumber,ProductName,Administered_Volume_L,Exhaled_Captured_Volume_L,Initial_Xe_Purity_Percent,Recovered_Xe_Purity_Percent,Recovered_CO2_ppm,Recovered_H2O_ppm,Recovered_O2_ppm,Min_Recovery_Eff,Max_CO2 XE-REC-2026-001,HP-Xe-129 (90% enriched),1.0,0.92,90.0,89.5,50.0,2.0,21.0,85.0,100.0 XE-REC-2026-002,HP-Xe-129 (85% enriched),0.8,0.60,85.0,84.0,150.0,8.0,21.0,85.0,100.0 XE-REC-2026-003,HP-Xe-129 (Recycled),1.0,0.95,92.0,91.8,20.0,1.0,21.0,85.0,100.0
FS — Functional Specification
| ID | Function | Implementation |
|---|---|---|
| FS-001 | CLI execution | ExhaledGasScavengingAndRecoveryQC.exe supports demo mode and input.csv output.json mode. |
| FS-002 | CSV import | Read UTF-8 CSV and validate header, column count and order. |
| FS-003 | Schema validation | Validate required values, empties, types and basic plausibility. |
| FS-004 | Domain rule engine | Apply explicit rules for “Exhaled Gas Scavenging & Recovery QC” and locally approved limits. |
| FS-005 | Status aggregation | FAIL for a critical finding; WARNING for a non-critical deviation; PASS for conformity. |
| FS-006 | JSON export | Write source values, applied rules, statuses, warnings, failures and configuration version. |
| FS-007 | Audit support | Retain a result structure suitable for review, investigation, IQ/OQ and change control. |
| FS-008 | Integration contract | LIMS/ELN/MES or an instrument wrapper creates CSV; the utility returns JSON. |
output.json example
{
"utilityId": "exhaled-gas-scavenging-and-recovery-qc",
"primaryTag": "medical_devices",
"overallStatus": "PASS|WARNING|FAIL",
"sourceFile": "input.csv",
"checks": [
{
"parameter": "BatchNumber",
"value": "XE-REC-2026-001",
"status": "PASS|WARNING|FAIL",
"message": "Rule-based check result"
},
{
"parameter": "ProductName",
"value": "HP-Xe-129 (90% enriched)",
"status": "PASS|WARNING|FAIL",
"message": "Rule-based check result"
},
{
"parameter": "Administered_Volume_L",
"value": "1.0",
"status": "PASS|WARNING|FAIL",
"message": "Rule-based check result"
},
{
"parameter": "Exhaled_Captured_Volume_L",
"value": "0.92",
"status": "PASS|WARNING|FAIL",
"message": "Rule-based check result"
},
{
"parameter": "Initial_Xe_Purity_Percent",
"value": "90.0",
"status": "PASS|WARNING|FAIL",
"message": "Rule-based check result"
},
{
"parameter": "Recovered_Xe_Purity_Percent",
"value": "89.5",
"status": "PASS|WARNING|FAIL",
"message": "Rule-based check result"
},
{
"parameter": "Recovered_CO2_ppm",
"value": "50.0",
"status": "PASS|WARNING|FAIL",
"message": "Rule-based check result"
},
{
"parameter": "Recovered_H2O_ppm",
"value": "2.0",
"status": "PASS|WARNING|FAIL",
"message": "Rule-based check result"
}
],
"warnings": [],
"criticalFindings": []
}
OQ/PQ test scenarios
| ID | Scenario | Expected result |
|---|---|---|
| OQ-001 | Valid example row | PASS or an allowed WARNING under local rules. |
| OQ-002 | Required column missing | Schema error; domain checks do not mask it. |
| OQ-003 | Non-numeric value in numeric field | Type-conversion error. |
| OQ-004 | Critical parameter outside its limit | FAIL and a critical finding. |
| OQ-005 | Boundary value | The result follows the configured ≤ / ≥ / < / > operator. |
| PQ-001 | Real site data | Agreed QA/QC review retaining CSV, JSON, version and checksum. |
QA/QC and change control
- Do not change column names without updating the validator, documentation and test set.
- Retain input.csv, output.json, executable version, rule version and checksums.
- Before production use, verify local limits and execute IQ/OQ/PQ or equivalent CSA.
- Changes affecting patient safety, dosimetry, gas composition, polarization or equipment require documented impact assessment.
Included in packages
Rph Hyperpolarized Xenon Lifecycle QC Suite
29 utilities for the hyperpolarized xenon lifecycle: isotope composition and gas purity, SEOP and polarization, T1/storage/transport, safe blending and delivery, MRI/SPECT QC, dosimetry, scavenging, recovery and recycling.
OpenRPH isotope family: xenon and gas tracers
Xe-127, Xe-129 and Xe-133 for ventilation, hyperpolarized imaging, gas QC and safety.
OpenRPH organ/system: pulmonary and ventilation
Lung perfusion, MAA, V/Q, aerosol, xenon ventilation, shunt and pulmonary dosimetry.
OpenRPH use case: xenon, ventilation and medical gases
Xe-129, Xe-133, Xe-127, hyperpolarization, SEOP, T1, mixing, scavenging, transport, recovery and ventilation imaging.
Open