ResidualSolventsGCQualityChecker

Residual Solvents GC Quality Checker — Residual Solvents Control (GC)

ℹ️ Utility checks residual solvent content according to ICH Q3C guidelines:
• Class 1 (Avoid): Benzene (≤2 ppm) — carcinogen
• Class 2 (Limit): Methanol (≤3000 ppm), Acetonitrile (≤410 ppm), Dichloromethane (≤600 ppm), Hexane (≤290 ppm)
• Class 3 (Low Toxicity): Ethyl Acetate (≤5000 ppm), Acetone (≤5000 ppm)
• Total Solvents (≤5000 ppm or 0.5%)

⚠️ CRITICAL: Benzene exceedance (>2 ppm) is unacceptable due to high carcinogenicity!
Exceedance of total solvents indicates insufficient drying or purification.

Usage:
ResidualSolventsGCQualityChecker.exe → demo mode (console output)
ResidualSolventsGCQualityChecker.exe input.csv output.json → evaluate your data

Input format:
BatchNumber,ProductName,MethanolPPM,AcetonitrilePPM,DichloromethanePPM,HexanePPM,EthylAcetatePPM,AcetonePPM,BenzenePPM,TotalSolventsPPM

Example:
API-2026-RS-001,Active Ingredient X,1500.0,200.0,300.0,100.0,2500.0,1000.0,0.5,5600.5

— WHY IS THIS NEEDED?
Residual solvents may be present in Active Pharmaceutical Ingredients (APIs) and excipients after synthesis or purification.
According to ICH Q3C, they are classified by toxicity:
• Class 1: Solvents to be avoided (known carcinogens or environmental toxins).
• Class 2: Solvents to be limited (non-genotoxic animal carcinogens or causing other irreversible toxic effects).
• Class 3: Solvents with low potential toxicity to humans.

⚠️ CRITICAL:
• Benzene ≤2 ppm — strict limit due to carcinogenicity. Even trace amounts are dangerous.
• Total Solvents ≤5000 ppm (0.5%) — standard limit for most APIs unless justified otherwise.
• Methanol ≤3000 ppm — often used in synthesis but toxic upon accumulation.
• Dichloromethane ≤600 ppm — potential carcinogen, requires strict control.

Key features:
• Check of solvents from all three ICH Q3C classes
• Strict control of Benzene (Class 1)
• Calculation and check of total solvents
• Generation of reports compatible with LIMS LabWare
• Support for multiple samples in one file

Critical parameters:
• Benzene: ≤2 ppm (Class 1)
• Methanol: ≤3000 ppm (Class 2)
• Acetonitrile: ≤410 ppm (Class 2)
• Dichloromethane: ≤600 ppm (Class 2)
• Hexane: ≤290 ppm (Class 2)
• Ethyl Acetate: ≤5000 ppm (Class 3)
• Acetone: ≤5000 ppm (Class 3)
• Total Sum: ≤5000 ppm

💡 Usage tips:
1. Analysis method: Gas Chromatography with Flame Ionization Detector (GC-FID) or Mass Spectrometry (GC-MS).
2. Sample preparation: Usually direct solution injection or HeadSpace method.
3. If the sum of individual solvents exceeds 5000 ppm, the batch is rejected, even if each individual solvent is within limits.
4. For Class 3 solvents, the limit may be higher if justified by the manufacturing process, but 5000 ppm is used by default.
5. Benzene must be determined with high sensitivity due to its low limit.

⚠️ Note: The presence of Class 1 solvents (e.g., benzene) should be completely excluded from the manufacturing process if possible. If their presence is unavoidable, they must be controlled using validated analytical procedures with detection limits appropriate to the level of toxicity.